Enzyme Engineering

Enzyme Engineering

Enzyme Engineering

Design, test, and iterate on your target sequence, optimizing for multiple properties

Design, test, and iterate on your target sequence, optimizing for multiple properties

Optimize

Improve thermostability, activity, and solubility

  • Test tens of thousands of variants in parallel through multiple rounds of evolution

  • Integrate experimental results into each round of machine learning, fine-tuning our AI for higher scoring in your property of interest


Optimize

Improve thermostability, activity, and solubility

  • Test tens of thousands of variants in parallel through multiple rounds of evolution

  • Integrate experimental results into each round of machine learning, fine-tuning our AI for higher scoring in your property of interest


Optimize

Improve thermostability, activity, and solubility

  • Test tens of thousands of variants in parallel through multiple rounds of evolution

  • Integrate experimental results into each round of machine learning, fine-tuning our AI for higher scoring in your property of interest


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Design

Enzymes targeted to your substrate

  • Scaffold an existing motif or diversify the sequence/structure of an existing binder

  • Generate de-novo protein structures targeted to your substrate

  • Optimize for kcat/km/binding affinity to a substrate

  • Generate sequences given Enzyme Commission annotations or starting sequences

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Design

Build effortless. Customize superfast.

  • Scaffold an existing motif or diversify the sequence/structure of an existing binder

  • Generate de-novo protein structures targeted to your substrate

  • Optimize for kcat/km/binding affinity to a substrate

  • Generate sequences given Enzyme Commission annotations or starting sequences

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Design

Enzymes targeted to your substrate

  • Scaffold an existing motif or diversify the sequence/structure of an existing binder

  • Generate de-novo protein structures targeted to your substrate

  • Optimize for kcat/km/binding affinity to a substrate

  • Generate sequences given Enzyme Commission annotations or starting sequences

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Molecular Dynamics

Apply physics-based methods for free energy calculations

  • Run molecular dynamics simulations to evaluate protein-ligand complex dynamic trajectories

  • Perform large scale protein-ligand docking

  • Predict system stability over time

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Molecular Dynamics

Apply physics-based methods for free energy calculations

  • Run molecular dynamics simulations to evaluate protein-ligand complex dynamic trajectories

  • Perform large scale protein-ligand docking

  • Predict system stability over time

Banner-3
Molecular Dynamics

Apply physics-based methods for free energy calculations

  • Run molecular dynamics simulations to evaluate protein-ligand complex dynamic trajectories

  • Perform large scale protein-ligand docking

  • Predict system stability over time

Structural modeling

Large scale structure prediction of proteins and protein-ligand complexes

  • Build a structure for your enzyme, incorporating templates

  • Model protein-ligand complexes given a sequence and ligands/cofactors

Structural modeling

Large scale structure prediction of proteins and protein-ligand complexes

  • Build a structure for your enzyme, incorporating templates

  • Model protein-ligand complexes given a sequence and ligands/cofactors

Structural modeling

Large scale structure prediction of proteins and protein-ligand complexes

  • Build a structure for your enzyme, incorporating templates

  • Model protein-ligand complexes given a sequence and ligands/cofactors